2023

  • Johansson, M. E., van Lier, N. M., Kessels, R. P., Bloem, B. R., & Helmich, R. C. (2023). Two-year clinical progression in focal and diffuse subtypes of Parkinson’s disease. npj Parkinson’s Disease, 9(1), 1-11.
  • Tosserams, A., Bloem, B.R., Ehgoetz Martens, K.A. et al. Modulating arousal to overcome gait impairments in Parkinson’s disease: how the noradrenergic system may act as a double-edged sword. Transl Neurodegener 12, 15 (2023). https://doi.org/10.1186/s40035-023-00347-z
  • Beckers, M., Bloem, M. B. R., Helmich, M. B. R. R. C. (2023). Mask on, Mask off: Subclinical Parkinson’s Disease Unveiled by COVID-19. Journal of Movement Disorders, 16(1), 55–58.
  • Bates, S., Dumoulin, S.O., Folkers, P.J.M. et al. A vision of 14 T MR for fundamental and clinical science. Magn Reson Mater Phy 36, 211–225 (2023). https://doi.org/10.1007/s10334-023-01081-3
  • Tichelaar, J. G., Sayalı, C. , Helmich, R.C. , & Cools, R. (2023). Impulse control disorder in Parkinson’s disease is associated with abnormal frontal value signalling. Brain, awad162, 1-14.

2022

  • Dirkx, Michiel F., and Matteo Bologna. “The pathophysiology of Parkinson’s disease tremor.” Journal of the Neurological Sciences (2022): 120196.
  • Nieuwhof F, Toni I, Dirkx MF, Gallea C, Vidailhet M, Buijink AWG, van Rootselaar AF, van de Warrenburg BPC, Helmich RC. Cerebello-thalamic activity drives an abnormal motor network into dystonic tremor (2022). Neuroimage Clin; 33:102919.
  • Deuschl G, Becktepe JS, Dirkx M, Haubenberger D, Hassan A, Helmich RC, Muthuraman M, Panyakaew P, Schwingenschuh P, Zeuner KE, Elble RJ. The clinical and electrophysiological investigation of tremor (2022). Clin Neurophysiol; 136:93-129.
  • Nieuwhof, F., Toni, I., Buijink, A. W. G., van Rootselaar, A. F., van de Warrenburg, B. P. C., & Helmich, R. C. (2022). Phase-locked transcranial electrical brain stimulation for tremor suppression in dystonic tremor syndromes. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 140, 239–250.
  • Johansson, Martin E., et al. “Aerobic exercise alters brain function and structure in Parkinson’s disease: a randomized controlled trial.” Annals of Neurology 91.2 (2022): 203-216.

2021

  • van den Berg, K. R., & Helmich, R. C. (2021). The role of the cerebellum in tremor–evidence from neuroimaging. Tremor and Other Hyperkinetic Movements, 11.
  • Van der Heide, A., Speckens, A. E., Meinders, M. J., Rosenthal, L. S., Bloem, B. R., & Helmich, R. C. (2021). Stress and mindfulness in Parkinson’s disease–a survey in 5000 patients. npj Parkinson’s Disease, 7(1), 1-10.
  • Van der Heide, A., Meinders, M. J., Speckens, A. E. M., Peerbolte, T. F., Bloem, B. R., & Helmich, R. C. (2021). Stress and Mindfulness in Parkinson’s Disease: Clinical Effects and Potential Underlying Mechanisms. Movement Disorders, 36(1), 64-70.
  • Helmich, R. C., Van den Berg, K. R., Panyakaew, P., Cho, H. J., Osterholt, T., McGurrin, P., … & Hallett, M. (2021). Cerebello‐Cortical Control of Tremor Rhythm and Amplitude in Parkinson’s Disease. Movement Disorders, 36(7), 1727.

2020

  • Van der Heide, A., Meinders, M. J., Bloem, B. R., & Helmich, R. C. (2020). The impact of the covid-19 pandemic on psychological distress, physical activity and symptom severity in Parkinson’s disease. Journal of Parkinson’s Disease, 10(4), 1355-1364.
  • Helmich RC, Bloem BR. The Impact of the COVID-19 Pandemic on Parkinson’s Disease: Hidden Sorrows and Emerging Opportunities (2020). J Parkinsons Dis. 10(2):351-354.
  • Zach H, Dirkx MF, Roth D, Pasman JW, Bloem BR, Helmich RC. Dopamine-responsive and dopamine-resistant resting tremor in Parkinson disease (2020). Neurology; 95: e1461–e1470.
  • Nieuwhof F, de Bie RMA, Praamstra P, van den Munckhof P, Helmich RC. The cerebral tremor circuit in a patient with Holmes tremor (2020). Ann Clin Transl Neurol: acn3.51143–6.
  • AMM van der Stouwe, F Nieuwhof, RC Helmich. Tremor pathophysiology: lessons from neuroimaging (2020). Current opinion in neurology 33 (4), 474-481.
  • Wardt JV, van der Stouwe AMM, Dirkx M, Elting JWJ, Post B, Tijssen MA, Helmich RC. Systematic clinical approach for diagnosing upper limb tremor (2020). J Neurol Neurosurg Psychiatry, 91(8):822-830.

2019 – 2015

  • Dirkx MF, Zach H, van Nuland A, Bloem BR, Toni I, Helmich RC. Cerebral differences between dopamine-resistant and dopamine-responsive Parkinson’s tremor (2019). Brain; 142(10):3144-3157
  • Fasano A, Helmich RC. Tremor habituation to deep brain stimulation: Underlying mechanisms and solutions (2019). Mov Disord;34(12):1761-1773.
  • Helmich RC. The cerebral basis of Parkinsonian tremor: a network perspective (2018). Mov Dis. 33(2):219-231.
  • Dirkx MF, Zach H, Bloem BR, Hallett M, Helmich RC. The nature of postural tremor in Parkinson’s disease (2018). Neurology, 27;90(13):e1095-e1103.
  • Zach, H., Dirkx, M. F., Pasman, J. W., Bloem, B. R., & Helmich, RC. (2017). Cognitive Stress Reduces the Effect of Levodopa on Parkinson’s Resting Tremor. CNS Neuroscience & Therapeutics, 23(3), 209–215.
  • Zach, H., Dirkx, M., Pasman, J. W., Bloem, B. R., & Helmich, RC. (2017). The patient’s perspective: The effect of levodopa on Parkinson symptoms. Parkinsonism and Related Disorders, 35, 48–54
  • Nieuwhof F, Bloem BR, Reelick MF, Aarts E, Maidan I, Mirelman A, Hausdorff JM, Toni I & Helmich RC. Impaired dual tasking in Parkinson is associated with reduced focusing of cortico-striatal activity (2017). Brain. 140(5):1384-1398.
  • Dirkx MF, den Ouden H, Aarts E, Timmer M, Bloem BR, Toni I, Helmich RC. The Cerebral Network of Parkinson’s Tremor: An Effective Connectivity fMRI Study (2016). J Neurosci. 36(19):5362-72.
  • Caligiore D, Helmich RC, Hallett M, Moustafa AA, Timmermann L, Toni I, & Baldassarre G. Parkinson’s disease as a systemlevel disorder (2016). npj Parkinson’s Disease 2, 16025.
  • Thaler A, Helmich RC, Or-Borichev A, van Nuenen BF, Shapira-Lichter I, Gurevich T, Orr-Urtreger A, Marder K, Bressman S, Bloem BR, Giladi N, Hendler T, Mirelman A. Intact working memory in non-manifesting LRRK2 carriers – an fMRI study (2016). Eur J Neurosci. 43(1):106-12.
  • Helmich RC, Thaler A, Van Nuenen BFL, Gurevich T, Mirelman A, Marder KS, Bressman S, Orr-Urtreger A, Giladi N, Bloem BR, Toni I. Reorganization of cortico-striatal circuits in healthy G2019S LRRK2 carriers (2015). Neurology. 84(4):399-406.

2014 – 2005

  • Thaler A, Artzi M, Mirelman A, Jacob Y, Helmich RC, Van Nuenen BFL, Gurevich T, Orr-Urtreger A, Marder K, Bressman S, Bloem BR, Hendler T, Giladi N, Ben Bashat D, and the LRRK2 Ashkenazi Jewish consortium. A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson’s disease related G2019S LRRK2 mutation carriers (2014). Mov Disord. 29(6):823-7.
  • Thaler A, Mirelman A, Helmich RC, Van Nuenen BFL, Rosenberg K, Gurevich T, Orr-Urtreger A, Marder K, Bressman S, Bloem BR, Giladi N, Hendler T. Neural correlates of executive functions in healthy G2019S LRRK2 mutation carriers (2013). Cortex, 49(9):2501-11.
  • Van Nuenen BF, Helmich RC, Ferraye M, Thaler A, Hendler T, Orr-Urtreger A, Mirelman A, Bressman S, Marder KS, Giladi N, Van de Warrenburg BP, Bloem BR, Toni I (2012). Cerebral pathological and compensatory mechanisms in the premotor phase of leucine-rich repeat kinase 2-parkinsonism. Brain, 135(Pt 12): 3687-3698.
  • Van Nuenen BF, Helmich RC, Buenen N, Van de Warrenburg BP, Bloem BR, Toni I (2012). Compensatory activity in the extrastriate body area of Parkinson’s disease patients. J Neurosci. 32(28):9546-53.
  • Helmich RC, Hallett M, Deuschl G, Toni I, Bloem BR (2012). Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits? Brain, 135 (Pt 11): 3206-26.
  • Helmich, R. C., Janssen, M. J., Oyen, W. J., Bloem, B. R., & Toni, I. (2011). Pallidal dysfunction drives a cerebellothalamic circuit into Parkinson tremor. Annals of neurology, 69(2), 269-281.
  • Helmich RC, Derikx L, Bakker M, Scheeringa R, Bloem BR, & Toni I (2010). Spatial remapping of cortico-striatal connectivity in Parkinson’s disease. Cerebral Cortex, 20(5): 1175-86.
  • Helmich RC, de Lange, FP, Bloem, BR, & Toni, I. (2007). Cerebral compensation during motor imagery in Parkinson’s disease. Neuropsychologia, 45: 2201-2215.