2026

• van den Berg, K. R., Johansson, M. E., Grill, F., Dirkx, M. F., Bloem, B. R., & Helmich, R. C. (2026). Large-scale antagonistic cerebral networks drive amplitude variability in Parkinson’s disease tremor. Brain, awag182.
• van den Berg, K.R.E. and Helmich, R.C. (2026), Re-Emergent Postural Tremor Without Clinical Resting Tremor in Parkinson’s Disease—A Case Report. Mov Disord Clin Pract. 
• Dirkx, J. E. M. C., Grill, F., Dijk, N., Cools, R., Booij, J., Bloem, B. R., Helmich, R. C. G., Ruhé, H. G., & van Beek, M. H. C. T. (2026). Depression in Parkinson’s disease is associated with reduced ventral striatal dopamine transporter binding. npj Parkinson’s Dis. 
• Dirkx, J. E. M., & van Beek, M. (2026) Psychiatrische stoornissen bij de ziekte van Parkinson. Huisarts en Wetenschap, 69, HnW-00000826.
• Timmermans, N.A., Bucur, I.G., Soriano, D.C., Post, E., Cagnan, H., Shin, S., Little, M.A., Raykov, Y.P., Bloem, B.R., Helmich, R.C. and Evers, L.J.W. (2026), Daily-Life, Sensor-Derived Tremor Measures Are Sensitive to Progression in Early Parkinson’s Disease. Ann Neurol, 00, 1-13. 
• Reniers, C.J.M., van Prooije, T.H., Kapteijns, K.C.J., van Asten, J.J.A., Mariotti, C., Sarro, L., Nigri, A., Grisoli, M., Coarelli, G., Durr, A., Scheenen, T. and van de Warrenburg, B. (2026), Early and Progressive Spinal Cord Atrophy in Spinocerebellar Ataxia Type 1. Mov Disord. 
• Visser, I. M., Nijhuis, F. A. P., van de Warrenburg, B., Helmich, R. C., & Snijders, A. H. (2026). Botulinetoxine bij armtremor. Tijdschrift voor Neurologie en Neurochirurgie, 127(2), 67–76.
• Oosterhof, T. H., de Vries, N. M., Bloem, B. R., & Darweesh, S. K. L. (2026). REM-slaapgedragsstoornis: In beweging om de ziekte van Parkinson te voorkomen. Tijdschrift voor Neurologie en Neurochirurgie, 127(2), 55–59.

2025

• Visser, I. M., Pitakpatapee, Y., van de Warrenburg, B., Helmich, R. C., Snijders, A. H., & Nijhuis, F. A. P. (2025). Botulinum toxin efficacy in upper limb tremor: A systematic review and meta-analysis. Mov Disord Clin Pract, 13: 369-378.
• Timmermans, N.A., Terranova, R., Soriano, D.C. et al. (2025). A generalizable and open-source algorithm for real-life monitoring of tremor in Parkinson’s disease. npj Parkinsons Dis., 11, 205.
• Angelini, L., Van Den Berg, K., Dirkx, M., Bologna, M., Bloem, B. R., & Helmich, R. C. (2025). Reliability of Neuroimaging and Neurophysiological Tremor Features in Parkinson’s Disease. Mov Disord, 40: 2177-2188.
• van der Heide, A., Wessel, M., Papadopetraki, D., Geurts, D.E.M., van Prooije, T.H., Gommans, F., Bloem, B.R., Dirkx, M.F. and Helmich, R.C. (2025). Propranolol Reduces Parkinson’s Tremor and Inhibits Tremor-Related Activity in the Motor Cortex: A Placebo-Controlled Crossover Trial. Annals of Neurology. 97, 741-752.
• van den Berg, K.R.E, Johansson, M.E., Dirkx, M.F., Bloem, B.R., & Helmich, R.C. (2025). Changes in Action Tremor in Parkinson’s Disease over Time: Clinical and Neuroimaging Correlates. Mov Disord, 40, 292-304.

2024

• Verhulst, M.L.H., Keijzer, H.M., van Gils, P.C.W., van Heugten, C.M., Meijer, F.J.A., Tonino, B.A.R., Bonnes, J.L., Delnoij, T.S., Hofmeijer, J., & Helmich, R.C. (2024). Functional connectivity in resting-state networks relates to short-term global cognitive functioning in cardiac arrest survivors. Hum Brain Mapp, 45:e26769.
• van Prooije, T. H., Kapteijns, K. C., van Asten, J. J., IntHout, J., Verbeek, M. M., Scheenen, T. W., & van de Warrenburg, B. P. (2024). Multimodal, Longitudinal Profiling of SCA1 Identifies Predictors of Disease Severity and Progression. Annals of Neurology, 96:774–787.
• Oosterhof, T. H., Darweesh, S. K., Bloem, B. R., & de Vries, N. M. (2024). Considerations on How to Prevent Parkinson’s Disease Through Exercise. Journal of Parkinson’s Disease, 14(s2), S395–S406.
• van der Heide, A., Goltz, F., de Vries, N.M. Bloem, B.R., Speckens, A.E., & Helmich, R.C. (2024). Study protocol for the MIND-PD study: a randomized controlled trial to investigate clinical and biological effects of mindfulness-based cognitive therapy in people with Parkinson’s disease. BMC Neurol, 24, 219.
• Goltz, F., van der Heide, A., & Helmich, R. C. (2024). Alleviating Stress in Parkinson’s Disease: Symptomatic Treatment, Disease Modification, or Both?. Journal of Parkinson’s disease, 14(s1), S147–S158.
• van der Heide, A., Dommershuijsen, L. J., Puhlmann, L. M., Kalisch, R., Bloem, B. R., Speckens, A. E., & Helmich, R. C. (2024). Predictors of stress resilience in Parkinson’s disease and associations with symptom progression. npj Parkinson’s Disease, 10(1), 81.
• van der Heide, A., Trenkwalder, C., Bloem, B. R., & Helmich, R. C. (2024). The Last Straw: How Stress Can Unmask Parkinson’s Disease. Journal of Parkinson’s Disease, 14(4), 889–893.
• Johansson, M. E., Toni, I., Kessels, R. P., Bloem, B. R., & Helmich, R. C. (2024). Clinical severity in Parkinson’s disease is determined by decline in cortical compensation. Brain, 147(3), 871–886.

2023

• Johansson, M. E., van Lier, N. M., Kessels, R. P., Bloem, B. R., & Helmich, R. C. (2023). Two-year clinical progression in focal and diffuse subtypes of Parkinson’s disease. npj Parkinson’s Disease, 9(1), 1-11.
• Tosserams, A., Bloem, B. R., Ehgoetz Martens, K. A., Helmich, R. C., Kessels, R. P. C., Shine, J. M., Taylor, N. L., Wainstein, G., Lewis, S. J. G., & Nonnekes, J. (2023). Modulating arousal to overcome gait impairments in Parkinson’s disease: how the noradrenergic system may act as a double-edged sword. Translational neurodegeneration, 12(1), 15.
• Beckers, M., Bloem, M. B. R., Helmich, M. B. R. R. C. (2023). Mask on, Mask off: Subclinical Parkinson’s Disease Unveiled by COVID-19. Journal of Movement Disorders, 16(1), 55–58.
• Bates, S., Dumoulin, S. O., Folkers, P. J., Formisano, E., Goebel, R., Haghnejad, A., … & Webb, A. (2023). A vision of 14 T MR for fundamental and clinical science. Magnetic Resonance Materials in Physics, Biology and Medicine, 36(2), 211-225.
• Tichelaar, J. G., Sayalı, C. , Helmich, R.C. , & Cools, R. (2023). Impulse control disorder in Parkinson’s disease is associated with abnormal frontal value signalling. Brain, awad162, 1-14.

2022

• Dirkx, M. F., & Bologna, M. (2022). The pathophysiology of Parkinson’s disease tremor. Journal of the Neurological Sciences, 435, 120196.
• Nieuwhof, F., Toni, I., Dirkx, M. F., Gallea, C., Vidailhet, M., Buijink, A. W., … & Helmich, R. C. (2022). Cerebello-thalamic activity drives an abnormal motor network into dystonic tremor. NeuroImage: Clinical, 33, 102919.
• Deuschl, G., Becktepe, J. S., Dirkx, M., Haubenberger, D., Hassan, A., Helmich, R. C., … & Elble, R. J. (2022). The clinical and electrophysiological investigation of tremor. Clinical Neurophysiology, 136, 93-129.
• Nieuwhof, F., Toni, I., Buijink, A. W., van Rootselaar, A. F., van de Warrenburg, B. P., & Helmich, R. C. (2022). Phase-locked transcranial electrical brain stimulation for tremor suppression in dystonic tremor syndromes. Clinical Neurophysiology, 140, 239-250.
• Johansson, M. E., Cameron, I. G., Van der Kolk, N. M., de Vries, N. M., Klimars, E., Toni, I., … & Helmich, R. C. (2022). Aerobic exercise alters brain function and structure in Parkinson’s disease: a randomized controlled trial. Annals of neurology, 91(2), 203-216.

2021

• van den Berg, K. R., & Helmich, R. C. (2021). The role of the cerebellum in tremor–evidence from neuroimaging. Tremor and Other Hyperkinetic Movements, 11.
• Van der Heide, A., Speckens, A. E., Meinders, M. J., Rosenthal, L. S., Bloem, B. R., & Helmich, R. C. (2021). Stress and mindfulness in Parkinson’s disease–a survey in 5000 patients. npj Parkinson’s Disease, 7(1), 1-10.
• Van der Heide, A., Meinders, M. J., Speckens, A. E. M., Peerbolte, T. F., Bloem, B. R., & Helmich, R. C. (2021). Stress and Mindfulness in Parkinson’s Disease: Clinical Effects and Potential Underlying Mechanisms. Movement Disorders, 36(1), 64-70.
• Helmich, R. C., Van den Berg, K. R., Panyakaew, P., Cho, H. J., Osterholt, T., McGurrin, P., … & Hallett, M. (2021). Cerebello‐Cortical Control of Tremor Rhythm and Amplitude in Parkinson’s Disease. Movement Disorders, 36(7), 1727.

2020

• Van der Heide, A., Meinders, M. J., Bloem, B. R., & Helmich, R. C. (2020). The impact of the covid-19 pandemic on psychological distress, physical activity and symptom severity in Parkinson’s disease. Journal of Parkinson’s Disease, 10(4), 1355-1364.
• Helmich RC, Bloem BR. The Impact of the COVID-19 Pandemic on Parkinson’s Disease: Hidden Sorrows and Emerging Opportunities (2020). J Parkinsons Dis. 10(2):351-354.
• Zach H, Dirkx MF, Roth D, Pasman JW, Bloem BR, Helmich RC. Dopamine-responsive and dopamine-resistant resting tremor in Parkinson disease (2020). Neurology; 95: e1461–e1470.
• Nieuwhof F, de Bie RMA, Praamstra P, van den Munckhof P, Helmich RC. The cerebral tremor circuit in a patient with Holmes tremor (2020). Ann Clin Transl Neurol: acn3.51143–6.
• AMM van der Stouwe, F Nieuwhof, RC Helmich. Tremor pathophysiology: lessons from neuroimaging (2020). Current opinion in neurology 33 (4), 474-481.
• Wardt JV, van der Stouwe AMM, Dirkx M, Elting JWJ, Post B, Tijssen MA, Helmich RC. Systematic clinical approach for diagnosing upper limb tremor (2020). J Neurol Neurosurg Psychiatry, 91(8):822-830.

2015 – 2019

• Dirkx MF, Zach H, van Nuland A, Bloem BR, Toni I, Helmich RC. Cerebral differences between dopamine-resistant and dopamine-responsive Parkinson’s tremor (2019). Brain; 142(10):3144-3157
• Fasano A, Helmich RC. Tremor habituation to deep brain stimulation: Underlying mechanisms and solutions (2019). Mov Disord;34(12):1761-1773.
• Helmich RC. The cerebral basis of Parkinsonian tremor: a network perspective (2018). Mov Dis. 33(2):219-231.
• Dirkx MF, Zach H, Bloem BR, Hallett M, Helmich RC. The nature of postural tremor in Parkinson’s disease (2018). Neurology, 27;90(13):e1095-e1103.
• Zach, H., Dirkx, M. F., Pasman, J. W., Bloem, B. R., & Helmich, RC. (2017). Cognitive Stress Reduces the Effect of Levodopa on Parkinson’s Resting Tremor. CNS Neuroscience & Therapeutics, 23(3), 209–215.
• Zach, H., Dirkx, M., Pasman, J. W., Bloem, B. R., & Helmich, RC. (2017). The patient’s perspective: The effect of levodopa on Parkinson symptoms. Parkinsonism and Related Disorders, 35, 48–54
• Nieuwhof F, Bloem BR, Reelick MF, Aarts E, Maidan I, Mirelman A, Hausdorff JM, Toni I & Helmich RC. Impaired dual tasking in Parkinson is associated with reduced focusing of cortico-striatal activity (2017). Brain. 140(5):1384-1398.
• Dirkx MF, den Ouden H, Aarts E, Timmer M, Bloem BR, Toni I, Helmich RC. The Cerebral Network of Parkinson’s Tremor: An Effective Connectivity fMRI Study (2016). J Neurosci. 36(19):5362-72.
• Caligiore D, Helmich RC, Hallett M, Moustafa AA, Timmermann L, Toni I, & Baldassarre G. Parkinson’s disease as a systemlevel disorder (2016). npj Parkinson’s Disease 2, 16025.
• Thaler A, Helmich RC, Or-Borichev A, van Nuenen BF, Shapira-Lichter I, Gurevich T, Orr-Urtreger A, Marder K, Bressman S, Bloem BR, Giladi N, Hendler T, Mirelman A. Intact working memory in non-manifesting LRRK2 carriers – an fMRI study (2016). Eur J Neurosci. 43(1):106-12.
• Helmich RC, Thaler A, Van Nuenen BFL, Gurevich T, Mirelman A, Marder KS, Bressman S, Orr-Urtreger A, Giladi N, Bloem BR, Toni I. Reorganization of cortico-striatal circuits in healthy G2019S LRRK2 carriers (2015). Neurology. 84(4):399-406.

2005 – 2014

• Thaler A, Artzi M, Mirelman A, Jacob Y, Helmich RC, Van Nuenen BFL, Gurevich T, Orr-Urtreger A, Marder K, Bressman S, Bloem BR, Hendler T, Giladi N, Ben Bashat D, and the LRRK2 Ashkenazi Jewish consortium. A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson’s disease related G2019S LRRK2 mutation carriers (2014). Mov Disord. 29(6):823-7.
• Thaler A, Mirelman A, Helmich RC, Van Nuenen BFL, Rosenberg K, Gurevich T, Orr-Urtreger A, Marder K, Bressman S, Bloem BR, Giladi N, Hendler T. Neural correlates of executive functions in healthy G2019S LRRK2 mutation carriers (2013). Cortex, 49(9):2501-11.
• Van Nuenen BF, Helmich RC, Ferraye M, Thaler A, Hendler T, Orr-Urtreger A, Mirelman A, Bressman S, Marder KS, Giladi N, Van de Warrenburg BP, Bloem BR, Toni I (2012). Cerebral pathological and compensatory mechanisms in the premotor phase of leucine-rich repeat kinase 2-parkinsonism. Brain, 135(Pt 12): 3687-3698.
• Van Nuenen BF, Helmich RC, Buenen N, Van de Warrenburg BP, Bloem BR, Toni I (2012). Compensatory activity in the extrastriate body area of Parkinson’s disease patients. J Neurosci. 32(28):9546-53.
• Helmich RC, Hallett M, Deuschl G, Toni I, Bloem BR (2012). Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits? Brain, 135 (Pt 11): 3206-26.
• Helmich, R. C., Janssen, M. J., Oyen, W. J., Bloem, B. R., & Toni, I. (2011). Pallidal dysfunction drives a cerebellothalamic circuit into Parkinson tremor. Annals of neurology, 69(2), 269-281.
• Helmich RC, Derikx L, Bakker M, Scheeringa R, Bloem BR, & Toni I (2010). Spatial remapping of cortico-striatal connectivity in Parkinson’s disease. Cerebral Cortex, 20(5): 1175-86.
• Helmich RC, de Lange, FP, Bloem, BR, & Toni, I. (2007). Cerebral compensation during motor imagery in Parkinson’s disease. Neuropsychologia, 45: 2201-2215.