• Johansson, M. E., van Lier, N. M., Kessels, R. P., Bloem, B. R., & Helmich, R. C. (2023). Two-year clinical progression in focal and diffuse subtypes of Parkinson’s disease. npj Parkinson’s Disease, 9(1), 1-11.
  • Tosserams, A., Bloem, B. R., Ehgoetz Martens, K. A., Helmich, R. C., Kessels, R. P. C., Shine, J. M., Taylor, N. L., Wainstein, G., Lewis, S. J. G., & Nonnekes, J. (2023). Modulating arousal to overcome gait impairments in Parkinson’s disease: how the noradrenergic system may act as a double-edged sword. Translational neurodegeneration12(1), 15.
  • Beckers, M., Bloem, M. B. R., Helmich, M. B. R. R. C. (2023). Mask on, Mask off: Subclinical Parkinson’s Disease Unveiled by COVID-19. Journal of Movement Disorders16(1), 55–58.
  • Bates, S., Dumoulin, S. O., Folkers, P. J., Formisano, E., Goebel, R., Haghnejad, A., … & Webb, A. (2023). A vision of 14 T MR for fundamental and clinical science. Magnetic Resonance Materials in Physics, Biology and Medicine36(2), 211-225.
  • Tichelaar, J. G., Sayalı, C. , Helmich, R.C. , & Cools, R. (2023). Impulse control disorder in Parkinson’s disease is associated with abnormal frontal value signalling. Brain, awad162, 1-14.



  • van den Berg, K. R., & Helmich, R. C. (2021). The role of the cerebellum in tremor–evidence from neuroimaging. Tremor and Other Hyperkinetic Movements11.
  • Van der Heide, A., Speckens, A. E., Meinders, M. J., Rosenthal, L. S., Bloem, B. R., & Helmich, R. C. (2021). Stress and mindfulness in Parkinson’s disease–a survey in 5000 patients. npj Parkinson’s Disease, 7(1), 1-10.
  • Van der Heide, A., Meinders, M. J., Speckens, A. E. M., Peerbolte, T. F., Bloem, B. R., & Helmich, R. C. (2021). Stress and Mindfulness in Parkinson’s Disease: Clinical Effects and Potential Underlying Mechanisms. Movement Disorders, 36(1), 64-70.
  • Helmich, R. C., Van den Berg, K. R., Panyakaew, P., Cho, H. J., Osterholt, T., McGurrin, P., … & Hallett, M. (2021). Cerebello‐Cortical Control of Tremor Rhythm and Amplitude in Parkinson’s Disease. Movement Disorders, 36(7), 1727.


  • Van der Heide, A., Meinders, M. J., Bloem, B. R., & Helmich, R. C. (2020). The impact of the covid-19 pandemic on psychological distress, physical activity and symptom severity in Parkinson’s disease. Journal of Parkinson’s Disease, 10(4), 1355-1364.
  • Helmich RC, Bloem BR. The Impact of the COVID-19 Pandemic on Parkinson’s Disease: Hidden Sorrows and Emerging Opportunities (2020). J Parkinsons Dis. 10(2):351-354.
  • Zach H, Dirkx MF, Roth D, Pasman JW, Bloem BR, Helmich RC. Dopamine-responsive and dopamine-resistant resting tremor in Parkinson disease (2020). Neurology; 95: e1461–e1470.
  • Nieuwhof F, de Bie RMA, Praamstra P, van den Munckhof P, Helmich RC. The cerebral tremor circuit in a patient with Holmes tremor (2020). Ann Clin Transl Neurol: acn3.51143–6.
  • AMM van der Stouwe, F Nieuwhof, RC Helmich. Tremor pathophysiology: lessons from neuroimaging (2020). Current opinion in neurology 33 (4), 474-481.
  • Wardt JV, van der Stouwe AMM, Dirkx M, Elting JWJ, Post B, Tijssen MA, Helmich RC. Systematic clinical approach for diagnosing upper limb tremor (2020). J Neurol Neurosurg Psychiatry, 91(8):822-830.

2019 – 2015

  • Dirkx MF, Zach H, van Nuland A, Bloem BR, Toni I, Helmich RC. Cerebral differences between dopamine-resistant and dopamine-responsive Parkinson’s tremor (2019). Brain; 142(10):3144-3157
  • Fasano A, Helmich RC. Tremor habituation to deep brain stimulation: Underlying mechanisms and solutions (2019). Mov Disord;34(12):1761-1773.
  • Helmich RC. The cerebral basis of Parkinsonian tremor: a network perspective (2018). Mov Dis. 33(2):219-231.
  • Dirkx MF, Zach H, Bloem BR, Hallett M, Helmich RC. The nature of postural tremor in Parkinson’s disease (2018). Neurology, 27;90(13):e1095-e1103.
  • Zach, H., Dirkx, M. F., Pasman, J. W., Bloem, B. R., & Helmich, RC. (2017). Cognitive Stress Reduces the Effect of Levodopa on Parkinson’s Resting Tremor. CNS Neuroscience & Therapeutics, 23(3), 209–215.
  • Zach, H., Dirkx, M., Pasman, J. W., Bloem, B. R., & Helmich, RC. (2017). The patient’s perspective: The effect of levodopa on Parkinson symptoms. Parkinsonism and Related Disorders, 35, 48–54
  • Nieuwhof F, Bloem BR, Reelick MF, Aarts E, Maidan I, Mirelman A, Hausdorff JM, Toni I & Helmich RC. Impaired dual tasking in Parkinson is associated with reduced focusing of cortico-striatal activity (2017). Brain. 140(5):1384-1398.
  • Dirkx MF, den Ouden H, Aarts E, Timmer M, Bloem BR, Toni I, Helmich RC. The Cerebral Network of Parkinson’s Tremor: An Effective Connectivity fMRI Study (2016). J Neurosci. 36(19):5362-72.
  • Caligiore D, Helmich RC, Hallett M, Moustafa AA, Timmermann L, Toni I, & Baldassarre G. Parkinson’s disease as a systemlevel disorder (2016). npj Parkinson’s Disease 2, 16025.
  • Thaler A, Helmich RC, Or-Borichev A, van Nuenen BF, Shapira-Lichter I, Gurevich T, Orr-Urtreger A, Marder K, Bressman S, Bloem BR, Giladi N, Hendler T, Mirelman A. Intact working memory in non-manifesting LRRK2 carriers – an fMRI study (2016). Eur J Neurosci. 43(1):106-12.
  • Helmich RC, Thaler A, Van Nuenen BFL, Gurevich T, Mirelman A, Marder KS, Bressman S, Orr-Urtreger A, Giladi N, Bloem BR, Toni I. Reorganization of cortico-striatal circuits in healthy G2019S LRRK2 carriers (2015). Neurology. 84(4):399-406.

2014 – 2005

  • Thaler A, Artzi M, Mirelman A, Jacob Y, Helmich RC, Van Nuenen BFL, Gurevich T, Orr-Urtreger A, Marder K, Bressman S, Bloem BR, Hendler T, Giladi N, Ben Bashat D, and the LRRK2 Ashkenazi Jewish consortium. A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson’s disease related G2019S LRRK2 mutation carriers (2014). Mov Disord. 29(6):823-7.
  • Thaler A, Mirelman A, Helmich RC, Van Nuenen BFL, Rosenberg K, Gurevich T, Orr-Urtreger A, Marder K, Bressman S, Bloem BR, Giladi N, Hendler T. Neural correlates of executive functions in healthy G2019S LRRK2 mutation carriers (2013). Cortex, 49(9):2501-11.
  • Van Nuenen BF, Helmich RC, Ferraye M, Thaler A, Hendler T, Orr-Urtreger A, Mirelman A, Bressman S, Marder KS, Giladi N, Van de Warrenburg BP, Bloem BR, Toni I (2012). Cerebral pathological and compensatory mechanisms in the premotor phase of leucine-rich repeat kinase 2-parkinsonism. Brain, 135(Pt 12): 3687-3698.
  • Van Nuenen BF, Helmich RC, Buenen N, Van de Warrenburg BP, Bloem BR, Toni I (2012). Compensatory activity in the extrastriate body area of Parkinson’s disease patients. J Neurosci. 32(28):9546-53.
  • Helmich RC, Hallett M, Deuschl G, Toni I, Bloem BR (2012). Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits? Brain, 135 (Pt 11): 3206-26.
  • Helmich, R. C., Janssen, M. J., Oyen, W. J., Bloem, B. R., & Toni, I. (2011). Pallidal dysfunction drives a cerebellothalamic circuit into Parkinson tremor. Annals of neurology, 69(2), 269-281.
  • Helmich RC, Derikx L, Bakker M, Scheeringa R, Bloem BR, & Toni I (2010). Spatial remapping of cortico-striatal connectivity in Parkinson’s disease. Cerebral Cortex, 20(5): 1175-86.
  • Helmich RC, de Lange, FP, Bloem, BR, & Toni, I. (2007). Cerebral compensation during motor imagery in Parkinson’s disease. Neuropsychologia, 45: 2201-2215.