2024

• Verhulst, M.L.H., Keijzer, H.M., van Gils, P.C.W., van Heugten, C.M., Meijer, F.J.A., Tonino, B.A.R., Bonnes, J.L., Delnoij, T.S., Hofmeijer, J., & Helmich, R.C. (2024). Functional connectivity in resting-state networks relates to short-term global cognitive functioning in cardiac arrest survivors. Hum Brain Mapp, 45:e26769.
• van Prooije, T. H., Kapteijns, K. C., van Asten, J. J., IntHout, J., Verbeek, M. M., Scheenen, T. W., & van de Warrenburg, B. P. (2024). Multimodal, Longitudinal Profiling of SCA1 Identifies Predictors of Disease Severity and Progression. Annals of Neurology, 96:774–787.
• Oosterhof, T. H., Darweesh, S. K., Bloem, B. R., & de Vries, N. M. (2024). Considerations on How to Prevent Parkinson’s Disease Through Exercise. Journal of Parkinson’s Disease, 14(s2), S395–S406.
• van der Heide, A., Goltz, F., de Vries, N.M. Bloem, B.R., Speckens, A.E., & Helmich, R.C. (2024). Study protocol for the MIND-PD study: a randomized controlled trial to investigate clinical and biological effects of mindfulness-based cognitive therapy in people with Parkinson’s disease. BMC Neurol, 24, 219.
• Goltz, F., van der Heide, A., & Helmich, R. C. (2024). Alleviating Stress in Parkinson’s Disease: Symptomatic Treatment, Disease Modification, or Both?. Journal of Parkinson’s disease, 14(s1), S147–S158.
• van der Heide, A., Dommershuijsen, L. J., Puhlmann, L. M., Kalisch, R., Bloem, B. R., Speckens, A. E., & Helmich, R. C. (2024). Predictors of stress resilience in Parkinson’s disease and associations with symptom progression. npj Parkinson’s Disease, 10(1), 81.
• van der Heide, A., Trenkwalder, C., Bloem, B. R., & Helmich, R. C. (2024). The Last Straw: How Stress Can Unmask Parkinson’s Disease. Journal of Parkinson’s Disease, 14(4), 889–893.
• Johansson, M. E., Toni, I., Kessels, R. P., Bloem, B. R., & Helmich, R. C. (2024). Clinical severity in Parkinson’s disease is determined by decline in cortical compensation. Brain, 147(3), 871–886.

2023

• Johansson, M. E., van Lier, N. M., Kessels, R. P., Bloem, B. R., & Helmich, R. C. (2023). Two-year clinical progression in focal and diffuse subtypes of Parkinson’s disease. npj Parkinson’s Disease, 9(1), 1-11.
• Tosserams, A., Bloem, B. R., Ehgoetz Martens, K. A., Helmich, R. C., Kessels, R. P. C., Shine, J. M., Taylor, N. L., Wainstein, G., Lewis, S. J. G., & Nonnekes, J. (2023). Modulating arousal to overcome gait impairments in Parkinson’s disease: how the noradrenergic system may act as a double-edged sword. Translational neurodegeneration, 12(1), 15.
• Beckers, M., Bloem, M. B. R., Helmich, M. B. R. R. C. (2023). Mask on, Mask off: Subclinical Parkinson’s Disease Unveiled by COVID-19. Journal of Movement Disorders, 16(1), 55–58.
• Bates, S., Dumoulin, S. O., Folkers, P. J., Formisano, E., Goebel, R., Haghnejad, A., … & Webb, A. (2023). A vision of 14 T MR for fundamental and clinical science. Magnetic Resonance Materials in Physics, Biology and Medicine, 36(2), 211-225.
• Tichelaar, J. G., Sayalı, C. , Helmich, R.C. , & Cools, R. (2023). Impulse control disorder in Parkinson’s disease is associated with abnormal frontal value signalling. Brain, awad162, 1-14.

2022

• Dirkx, M. F., & Bologna, M. (2022). The pathophysiology of Parkinson’s disease tremor. Journal of the Neurological Sciences, 435, 120196.
• Nieuwhof, F., Toni, I., Dirkx, M. F., Gallea, C., Vidailhet, M., Buijink, A. W., … & Helmich, R. C. (2022). Cerebello-thalamic activity drives an abnormal motor network into dystonic tremor. NeuroImage: Clinical, 33, 102919.
• Deuschl, G., Becktepe, J. S., Dirkx, M., Haubenberger, D., Hassan, A., Helmich, R. C., … & Elble, R. J. (2022). The clinical and electrophysiological investigation of tremor. Clinical Neurophysiology, 136, 93-129.
• Nieuwhof, F., Toni, I., Buijink, A. W., van Rootselaar, A. F., van de Warrenburg, B. P., & Helmich, R. C. (2022). Phase-locked transcranial electrical brain stimulation for tremor suppression in dystonic tremor syndromes. Clinical Neurophysiology, 140, 239-250.
• Johansson, M. E., Cameron, I. G., Van der Kolk, N. M., de Vries, N. M., Klimars, E., Toni, I., … & Helmich, R. C. (2022). Aerobic exercise alters brain function and structure in Parkinson’s disease: a randomized controlled trial. Annals of neurology, 91(2), 203-216.

2021

• van den Berg, K. R., & Helmich, R. C. (2021). The role of the cerebellum in tremor–evidence from neuroimaging. Tremor and Other Hyperkinetic Movements, 11.
• Van der Heide, A., Speckens, A. E., Meinders, M. J., Rosenthal, L. S., Bloem, B. R., & Helmich, R. C. (2021). Stress and mindfulness in Parkinson’s disease–a survey in 5000 patients. npj Parkinson’s Disease, 7(1), 1-10.
• Van der Heide, A., Meinders, M. J., Speckens, A. E. M., Peerbolte, T. F., Bloem, B. R., & Helmich, R. C. (2021). Stress and Mindfulness in Parkinson’s Disease: Clinical Effects and Potential Underlying Mechanisms. Movement Disorders, 36(1), 64-70.
• Helmich, R. C., Van den Berg, K. R., Panyakaew, P., Cho, H. J., Osterholt, T., McGurrin, P., … & Hallett, M. (2021). Cerebello‐Cortical Control of Tremor Rhythm and Amplitude in Parkinson’s Disease. Movement Disorders, 36(7), 1727.

2020

• Van der Heide, A., Meinders, M. J., Bloem, B. R., & Helmich, R. C. (2020). The impact of the covid-19 pandemic on psychological distress, physical activity and symptom severity in Parkinson’s disease. Journal of Parkinson’s Disease, 10(4), 1355-1364.
• Helmich RC, Bloem BR. The Impact of the COVID-19 Pandemic on Parkinson’s Disease: Hidden Sorrows and Emerging Opportunities (2020). J Parkinsons Dis. 10(2):351-354.
• Zach H, Dirkx MF, Roth D, Pasman JW, Bloem BR, Helmich RC. Dopamine-responsive and dopamine-resistant resting tremor in Parkinson disease (2020). Neurology; 95: e1461–e1470.
• Nieuwhof F, de Bie RMA, Praamstra P, van den Munckhof P, Helmich RC. The cerebral tremor circuit in a patient with Holmes tremor (2020). Ann Clin Transl Neurol: acn3.51143–6.
• AMM van der Stouwe, F Nieuwhof, RC Helmich. Tremor pathophysiology: lessons from neuroimaging (2020). Current opinion in neurology 33 (4), 474-481.
• Wardt JV, van der Stouwe AMM, Dirkx M, Elting JWJ, Post B, Tijssen MA, Helmich RC. Systematic clinical approach for diagnosing upper limb tremor (2020). J Neurol Neurosurg Psychiatry, 91(8):822-830.

2015 – 2019

• Dirkx MF, Zach H, van Nuland A, Bloem BR, Toni I, Helmich RC. Cerebral differences between dopamine-resistant and dopamine-responsive Parkinson’s tremor (2019). Brain; 142(10):3144-3157
• Fasano A, Helmich RC. Tremor habituation to deep brain stimulation: Underlying mechanisms and solutions (2019). Mov Disord;34(12):1761-1773.
• Helmich RC. The cerebral basis of Parkinsonian tremor: a network perspective (2018). Mov Dis. 33(2):219-231.
• Dirkx MF, Zach H, Bloem BR, Hallett M, Helmich RC. The nature of postural tremor in Parkinson’s disease (2018). Neurology, 27;90(13):e1095-e1103.
• Zach, H., Dirkx, M. F., Pasman, J. W., Bloem, B. R., & Helmich, RC. (2017). Cognitive Stress Reduces the Effect of Levodopa on Parkinson’s Resting Tremor. CNS Neuroscience & Therapeutics, 23(3), 209–215.
• Zach, H., Dirkx, M., Pasman, J. W., Bloem, B. R., & Helmich, RC. (2017). The patient’s perspective: The effect of levodopa on Parkinson symptoms. Parkinsonism and Related Disorders, 35, 48–54
• Nieuwhof F, Bloem BR, Reelick MF, Aarts E, Maidan I, Mirelman A, Hausdorff JM, Toni I & Helmich RC. Impaired dual tasking in Parkinson is associated with reduced focusing of cortico-striatal activity (2017). Brain. 140(5):1384-1398.
• Dirkx MF, den Ouden H, Aarts E, Timmer M, Bloem BR, Toni I, Helmich RC. The Cerebral Network of Parkinson’s Tremor: An Effective Connectivity fMRI Study (2016). J Neurosci. 36(19):5362-72.
• Caligiore D, Helmich RC, Hallett M, Moustafa AA, Timmermann L, Toni I, & Baldassarre G. Parkinson’s disease as a systemlevel disorder (2016). npj Parkinson’s Disease 2, 16025.
• Thaler A, Helmich RC, Or-Borichev A, van Nuenen BF, Shapira-Lichter I, Gurevich T, Orr-Urtreger A, Marder K, Bressman S, Bloem BR, Giladi N, Hendler T, Mirelman A. Intact working memory in non-manifesting LRRK2 carriers – an fMRI study (2016). Eur J Neurosci. 43(1):106-12.
• Helmich RC, Thaler A, Van Nuenen BFL, Gurevich T, Mirelman A, Marder KS, Bressman S, Orr-Urtreger A, Giladi N, Bloem BR, Toni I. Reorganization of cortico-striatal circuits in healthy G2019S LRRK2 carriers (2015). Neurology. 84(4):399-406.

2005 – 2014

• Thaler A, Artzi M, Mirelman A, Jacob Y, Helmich RC, Van Nuenen BFL, Gurevich T, Orr-Urtreger A, Marder K, Bressman S, Bloem BR, Hendler T, Giladi N, Ben Bashat D, and the LRRK2 Ashkenazi Jewish consortium. A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson’s disease related G2019S LRRK2 mutation carriers (2014). Mov Disord. 29(6):823-7.
• Thaler A, Mirelman A, Helmich RC, Van Nuenen BFL, Rosenberg K, Gurevich T, Orr-Urtreger A, Marder K, Bressman S, Bloem BR, Giladi N, Hendler T. Neural correlates of executive functions in healthy G2019S LRRK2 mutation carriers (2013). Cortex, 49(9):2501-11.
• Van Nuenen BF, Helmich RC, Ferraye M, Thaler A, Hendler T, Orr-Urtreger A, Mirelman A, Bressman S, Marder KS, Giladi N, Van de Warrenburg BP, Bloem BR, Toni I (2012). Cerebral pathological and compensatory mechanisms in the premotor phase of leucine-rich repeat kinase 2-parkinsonism. Brain, 135(Pt 12): 3687-3698.
• Van Nuenen BF, Helmich RC, Buenen N, Van de Warrenburg BP, Bloem BR, Toni I (2012). Compensatory activity in the extrastriate body area of Parkinson’s disease patients. J Neurosci. 32(28):9546-53.
• Helmich RC, Hallett M, Deuschl G, Toni I, Bloem BR (2012). Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits? Brain, 135 (Pt 11): 3206-26.
• Helmich, R. C., Janssen, M. J., Oyen, W. J., Bloem, B. R., & Toni, I. (2011). Pallidal dysfunction drives a cerebellothalamic circuit into Parkinson tremor. Annals of neurology, 69(2), 269-281.
• Helmich RC, Derikx L, Bakker M, Scheeringa R, Bloem BR, & Toni I (2010). Spatial remapping of cortico-striatal connectivity in Parkinson’s disease. Cerebral Cortex, 20(5): 1175-86.
• Helmich RC, de Lange, FP, Bloem, BR, & Toni, I. (2007). Cerebral compensation during motor imagery in Parkinson’s disease. Neuropsychologia, 45: 2201-2215.